A team of mathematicians from San Francisco State University and the University of North Carolina, Charlotte, has used mathematical modeling to uncover new clues to the three-dimensional organization of mitochondrial DNA in trypanosomes.
Trypanosomes are microscopic, unicellular parasites responsible for widespread, fatal diseases including sleeping sickness. This neglected disease, transmitted by the tse-tse fly, threatens millions of people in sub-Saharan Africa. Its western counterpart, Chagas disease, affects an estimated 8 to 11 million people across North and South America. Read more!
Caption: Network of oriented flat minicirles on a square grid. A tightly packed grid yields high levels of interlocking to form a large network of minicircles. This provides a model for the organization of DNA minicircles in the mitochondria of trypanosomes.
Credit: Javier Arsuaga, San Francisco State University